Perhaps the most overlooked benefit of grapefruit is its ability to help your gut microbiome. While these advantages are wonderful, they only skim the surface of what grapefruit can do for you – and your skin. Lowering these risk factors promotes good heart health and reduces the likelihood of heart disease. Grapefruit’s potassium and fiber content may be responsible for helping to lower cholesterol levels by 15%. Studies have shown that those who eat grapefruit regularly showed improvements in blood pressure and “bad” cholesterol levels. Helps improve blood pressure and cholesterol levels Keep juice in your lunch bag or a grapefruit in your purse to stay healthy on the go! Research shows that vitamin C can help shorten sickness time for colds grapefruit juice offers the same benefit. Vitamin C is synonymous with immune health: its antioxidant content means better protection from microbes. Grapefruit is composed of mostly water, so it can help provide plenty of hydration for your system. Luckily, you can supplement your water intake with water-rich foods. Hydration is important to maintaining the appearance of your skin – and dry or dehydrated skin will mean more visible fine lines and wrinkles. Enough vitamin C (both via food and beverages and topically) is also key for supporting collagen, and a brighter overall complexion. Its high levels of vitamin C are especially important to skin health when ingested, this nutrient plays a role in helping your skin protect itself against UV rays. Grapefruit juice benefits include its potassium, vitamin C, and magnesium content, among others. The same goes with drinking grapefruit juice and experiencing its far-reaching benefits. More sugar means more inflammation in our body and skin. What goes into the body will inevitably show up on our skin for example, more water means a more hydrated appearance. This pink wonderfruit has many advantages, both directly and indirectly related to skin health. This food-drug interaction appears to be novel and may be relevant to other fruit juices and drugs.4 Grapefruit Juice Benefits for Your Health A much higher volume caused an additional modest effect, possibly from reduced intestinal concentration and transit time of fexofenadine. Grapefruit juice at a commonly consumed volume diminished the oral bioavailability of fexofenadine sufficiently to be pertinent clinically, likely by direct inhibition of uptake by intestinal organic anion transporting polypeptide A (OATP-A new nomenclature, OATP1A2). Grapefruit juice, 300 mL and 1200 mL, reduced the coefficient of variation of the AUC of fexofenadine by 2-fold compared with that with a matching volume of water. The 1200-mL volume of grapefruit juice decreased the AUC of fexofenadine more than the 300-mL volume of grapefruit juice compared with the corresponding volume of water in each subject by a constant amount. This decline correlated with baseline AUC of fexofenadine with water at equivalent volume (r(2) = 0.97, P <. The 300-mL volume of grapefruit juice diminished the AUC of fexofenadine variably among individuals. 001), respectively, of those with the corresponding volume of water. 001), respectively, of those with the corresponding volume of water, and 1200 mL grapefruit juice reduced these parameters to 36% ( P <. The 300-mL volume of grapefruit juice decreased the mean area under the plasma drug concentration-time curve (AUC) and the peak plasma drug concentration of fexofenadine to 58% (P <. Grapefruit juice or water at normal (300 mL) or high (1200 mL) volume was ingested concomitantly with 120 mg fexofenadine by 12 healthy volunteers in a randomized 4-way crossover study, and fexofenadine pharmacokinetics were determined over a period of 8 hours. The purpose of this study was to elucidate the potential clinical relevance and mechanism(s) of action of 2 different volumes of grapefruit juice on the reduction of bioavailability of fexofenadine, a substrate of organic anion transporting polypeptides.
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